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    Background:  

    This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change 

    in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated 

    by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-

    activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of 

    intracellular levels of GEFs and GAPs.