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    RAN, member RAS oncogene family

    Background:  

    RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is 

    essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also

    involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence 

    of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis.