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    Background:  

    ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. 

    ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. Small GTP-binding protein which 

    cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by

    guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal 

    cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and 

    PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms