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    Background:  

    Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid 

    domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal 

    mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer 

    and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene

    and two other related trefoil family member genes are found in a cluster on chromosome 21.