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    Background:  

    This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules 

    and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell 

    shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in 

    neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins 

    involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach 

    to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human

    patients. [provided by RefSeq, Aug 2017]