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    Background:  

    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). 

    AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and 

    adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for

    transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. 

    Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon.

    Mutations in this gene are a  cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and

    ovarian cancer. Alternative  splicing results in multiple transcript variants